Scientist - Cell Biology

Javelin develops next generation in vitro pharmacology platforms that provide actionable insights into how drugs perform in humans. Our platform integrates human tissue chips, also known as microphysiological systems or organs-on-chip, with translational software to provide predictive solutions for drug discovery. Javelin’s Liver Tissue Chip sustains long-term metabolically active liver culture for applications in Drug Metabolism &
Pharmacokinetics, Drug Safety/Tox, Gene Therapy, and Pharmacology.

Position Summary

The Javelin Biotech R&D team is seeking a talented and motivated individual with experience in Cell Biology and Complex In Vitro Models (CIVM). The R&D team is responsible for developing tissue models which recapitulate the phenotypic and molecular functions that are important to drug discovery and development. This role will involve developing and characterizing primary human tissue models and establishing assays for tissue function and application-specific requirements. Expertise in primary human cells (emphasis on liver, kidney, and/or gastrointestinal tissue biology) and molecular biology techniques, including quantitative polymerase chain reaction (qPCR), ELISA/immuno-assays, and immunohistochemistry, are integral to this position. The successful candidate will apply their scientific experience towards expanding our in vitro modeling capabilities for new pharmacological applications.

Responsibilities:

• Develop and implement state-of-the-art CIVM, including normal and diseased tissue, using Javelin’s tissue chip platform
• Conduct experiments using Cell Biology and bioengineering tools (primary human tissue culture, microscopy, biochemical/immuno-based assays, qPCR)
• Independently design and execute studies, analyze and interpret data, and present findings back to the project team
• Collaborate and communicate data clearly and concisely within a multidisciplinary team, including tissue engineering, hardware engineering, computational biology, and product development
• Stay current with the latest advancements in CIVM and contribute to the development of innovative approaches and contexts-of-use
• Assist in writing and preparation of grant proposals, manuscripts, and reports and participate in professional activities related to research
• Provide mentorship and training for team members in specialized protocols and equipment use. Contribute critical scientific input to experiment designs.

Qualifications:

• PhD degree in Cellular or Molecular Biology, Bioengineering, Chemical Engineering, or a related discipline with 0+ years of relevant experience, or MS degree with 2+ years of relevant experience. Appointment level will depend on skill set and years of experience.
• Outstanding laboratory technique: primary human cell culture; microscopy (phase contrast, fluorescence, and confocal), protein and gene expression analysis, immuno-, biochemical & bioanalytical assays
• Strong experience with primary human complex in vitro models (liver, kidney, gut) including microphysiological systems, 3D cultures, spheroids, and organ-on-chip; experience with immune components and disease models is a strong plus
• Detail-oriented and scientifically driven with solid reasoning skills in experimental design, data analysis, and interpretation
• Excellent written and verbal communication skills; ability to follow complex instructions, multitask, carefully document work in written records.
• Strong data analysis and statistical skills (e.g., Prism, R-studio, etc.)
• Able to work well under direction as well as independently to achieve scientific and corporate milestones
• Demonstrated ability to work in a cross-functional team and/or lead a small team effectively in a multidisciplinary, fast-paced, dynamic, and results-oriented environment
• Available to start within 4-6 weeks

Compensation: Javelin Biotech offers a compensation package that includes a competitive salary based on experience, full health insurance, company contribution for dental and vision insurance, company match 401(k), and stock options.

Job type: permanent, full-time, on-location

Interested candidates should submit a cover letter and CV/resume with their application.

Job Type: Full-time

Pay: $85,000.00 - $115,000.00 per year

Benefits:

• 401(k)
• Dental insurance
• Health insurance
• Paid time off
• Vision insurance

Schedule:

• Monday to Friday

Application Question(s):

• Do you have experience with Complex In Vitro Models, such as microphysiological systems, 3D cultures, spheroids, or organ-on-chip?

Education:

• Master's (Required)

Experience:

• primary cell/tissue culture: 1 year (Required)

Work Location: In person