Research Scientist Ii - Biosensor

Req ID #: 221799
Location:South San Francisco, CA, US, 94080
For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

JOB SUMMARY

We are seeking a Research Scientist II - Biosensor for our Discovery site located in South San Francisco, CA.
Serve as scientific team member conducting routine analysis of biotherapeutics in antibody discovery projects. Responsible for providing quantitative analysis, developing new analytical methods and data interpretation of biophysical characterization of protein-protein interactions and immunoassays.

Essential responsibilities include:

• Perform biomolecular interactions with BLI/SPR platforms
• Design, troubleshoot, and analyze experiments discovery programs with label-free biosensor analysis.
• Characterize biotherapeutics by developing biosensor assays to quantitate antibody-target binding (e.g. kinetics, affinities) with high-throughput screens on various biosensor platforms
• Perform high-throughput epitope binning experiments
• Performed high-resolution kinetics and affinity analysis of antibody-antigen binding and other protein interactions
• Function as the primary contact for the planning and execution of antibody discovery projects related to research and method development, and for the design, planning, conduct and reporting of experiments.
• Ensure raw data is accurate, complete and in appropriate order to meet protocols and SOP specifications. Prepare high quality final reports appropriate for the project including method development, qualification, and data analysis.
• Provide oversight of the laboratory and mentor junior staff in areas such as protocol interpretation, method development and refinement, troubleshooting, and technique validation. Provide scientific expertise in experimental design, and interpretation.
• Multi-task effectively to triage and manage multiple projects
• Must be able attend and present at scientific meetings with clients.

JOB QUALIFICATIONS

The following are minimum requirements related to the Research Scientist II position.

• Education: Bachelor’s degree (B.S./B.A.) or Master’s degree (M.S./M.A.) in a scientific related discipline. Ph.D. preferred.
• Experience: Minimum of 8 years related experience in academic or biopharmaceutical industry. Minimum of 3 years of hands-on experience with biosensors is essential. Experience with other immunoassay platforms and/or flow cytometry is an asset.
• An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above.
• Other: Strong analytical, troubleshooting and problem-solving skills. Demonstrate leadership skills as they pertain to intra- and interdepartmental initiatives, sponsor interactions, and business development. Effective written and verbal communication skills. Ability to handle multiple projects, prioritize work and meet deadlines. Proficiency in the use of different biosensors and strong understanding of label-free principles is required. Must have hands-on experience with BLI/SPR platforms.

The pay range for this position is $111,000-$122,500. Please note that salaries vary within the range based on factors including, but not limited to, experience, skills, education, certifications, and location.

• Perform biomolecular interactions with BLI/SPR platforms
• Design, troubleshoot, and analyze experiments discovery programs with label-free biosensor analysis.
• Characterize biotherapeutics by developing biosensor assays to quantitate antibody-target binding (e.g. kinetics, affinities) with high-throughput screens on various biosensor platforms
• Perform high-throughput epitope binning experiments
• Performed high-resolution kinetics and affinity analysis of antibody-antigen binding and other protein interactions
• Function as the primary contact for the planning and execution of antibody discovery projects related to research and method development, and for the design, planning, conduct and reporting of experiments.
• Ensure raw data is accurate, complete and in appropriate order to meet protocols and SOP specifications. Prepare high quality final reports appropriate for the project including method development, qualification, and data analysis.
• Provide oversight of the laboratory and mentor junior staff in areas such as protocol interpretation, method development and refinement, troubleshooting, and technique validation. Provide scientific expertise in experimental design, and interpretation.
• Multi-task effectively to triage and manage multiple projects
• Must be able attend and present at scientific meetings with clients