Research Associate - Dmpk Dice

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At DICE Therapeutics (a wholly owned subsidiary of Eli Lilly and Co), we design and develop innovative therapies in immunology for patients with debilitating disease. Seeking to create a future where convenient oral medicines with biologic-like efficacy are available to patients with serious medical conditions, we are developing oral alternatives to medicines currently limited to injectable forms.

We seek an exceptional full-time lab-based Research Associate to join our Drug Metabolism and Pharmacokinetics (DMPK) team. This individual will be a key contributor to performing standard ADME/DMPK assays, such as microsomal stability, plasma protein binding, and metabolite identification. The individual will also be responsible for operating LC-MS instruments (QQQ and HRMS) with minimal direction.

Do you have experience in mass spectrometry while doing enzyme related work? This role may be perfect for you! Read on for more.

Key Responsibilities:

• Perform ADME/DMPK assays such as microsome stability, plasma protein binding, reaction phenotyping, metabolite identification, etc. across drug discovery and development programs.
• Develop, qualify, and/or validate methods on LC-MS/MS, Orbitrap HRMS, and other analytical platforms.
• Analyze in vitro and in vivo samples for drugs and metabolites for applications in pharmacokinetics, toxicokinetics, biomarker, etc. studies.
• Prepare and present weekly DMPK updates and provide written procedures and reports.
• Collaborate with colleagues in Synthetic Chemistry, CMC, Clinical Pharmacology, and other relevant divisions within the company.

Minimum Qualifications:

• BS or MS in chemistry
• 0-6 years industry experience

Preferences:

• Focus on analytical chemistry or biochemistry
• Academic and/or industry experience with ADME, DMPK, and/or Pharmacology
• Experience with chromatography techniques – HPLC, UPLC, etc.
• Experience in applications of mass spectrometry in bioanalysis. Hands-on experience with high resolution mass spectrometry (HRMS) and/or quantitative LC-MS/MS (e.g., multiple reaction monitoring or MRM assays)
• Experience with handling biological samples such as plasma, tissues, etc. for applications in bioanalytical assays

Lilly currently anticipates that the base salary for this position could range from between $77,000 to $175,000 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Of course, the compensation described above is subject to change and could be higher or lower than the range described above. Further, Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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