QSP Modeling Scientist

Simulations Plus is a leading developer of modeling and simulation software, and a provider of consulting services. We support our pharmaceutical and biotechnology clients through drug discovery, development research, and regulatory submissions.

Leadership truly cares about maintaining a positive culture and for employee well-being. We offer fully remote work, flexible schedules, unlimited vacation along with free medical premiums, stock options, bonus potential, and more!

The QSP Modeling Scientist will lead the mathematical representation of core areas within the DILIsym Services areas of expertise, some core areas include mitochondrial dysfunction, bile acid transport, immune response/cell death, biomarkers, pharmacokinetics, lipotoxicity, NAFLD and NASH, IPF, and kidney injury.

Business Unit: Quantitative Systems Pharmacology (QSP)

Department: Scientific

Location: This position can be 100% remote or hybrid near one of our locations (Buffalo, NY; Durham, NC; Lancaster, CA; or Pittsburgh, PA)

Job Responsibilities:

• Design, write, test, and use computer code to build and maintain the sub-model(s) related to a given core area (e.g. DILIsym, NAFLDsym, IPFsym, RENAsym, RADAsym)
• Represent compounds and drugs in DILIsym, including translating laboratory data into model parameters
• Contribute to the activities required for successful completion of all goals, including those of the various development efforts and the DILI-sim Initiative consortium
• Combine technical and project management work, including components such as systems pharmacology modeling, software code development, and maintenance in MATLAB or other designated software environments
• Develop plans to complete all tasks and provide all deliverables within a time frame consistent with the services agreement signed with the sponsor
• Schedule the necessary meetings including internal and external collaborators
• Travel to sponsor locations to participate in key milestone meetings as required
• Exerts leadership in the area of report and presentation preparation, which are critical final deliverables for all projects
• Manage and participate in preparation and review of all joint manuscripts between the DILIsym Services and the sponsor
• Ensure the effort expended for a given project remains consistent with the resources allocated for the project per the signed contract
• Publish work in scientific journals, with minimal review required by their supervisor, including documentation preparation, text development, figure development, and correspondence with editors and peer reviewers
• Oversee and supervise the technical work of others and mentor less experienced scientists
• Train others on QSP/QST and the various DSS platforms
• Other duties as assigned

Qualifications:

• 10+ years of QSP/QST modeling experience
• Proficiency in mathematics
• General knowledge of biology, biochemistry, lipid biochemistry, immunology,
• and/or toxicology
• Experience with Julia, MATLAB, GastroPlus™, DILIsym, C++ programming
• PK modeling, PKPD modeling, and systems pharmacology modeling
• Understand development process and how to apply modeling and simulation for maximum impact
• Strong verbal and written communication skills
• Maintain a positive attitude while interacting with colleagues and clients
• Must be able to multitask and have good organizational skills
• Self-motivated with ability to work with minimal supervision
• Minimal travel required up to 10%

Education:

• Masters in pharmaceutical science, biomedical engineering, or related life sciences field
• PhD in pharmaceutical science, biomedical engineering, or related life sciences field preferred

Find out more about how amazing it is to work at Simulations Plus by visiting www.simulations-plus.com/career-center and apply today!