Principal Scientist, In Vivo Pharmacologist

Principal Scientist, In Vivo Pharmacologist

About Us

Our mission is to develop transformational genetic medicines utilizing novel gene editing delivery technologies, with an emphasis on diseases with significant unmet medical need. Our team is advancing multiple innovative approaches to deliver a variety of therapeutic payloads, focusing initially on gene editing in therapeutically relevant cells and tissues. Our world class scientific founders include Professor David Liu (HHMI, Broad and Harvard) and Professor Keith Joung (MGH and Harvard), and we are funded with a significant capital investment by leading life science venture capital firms including Newpath Partners, Atlas Venture, F-Prime Capital, and 5AM Ventures. We believe that our technology has the potential to positively impact patients suffering from severe genetic diseases, and we are committed to building an excellent, science-driven and diverse team that is passionate about making a difference. Nvelop Therapeutics is a stealth-mode biotechnology company based in Cambridge, MA.

Position Overview

We are seeking a talented and growth-oriented In Vivo Pharmacologist to join our team. The successful candidate will lead efforts to establish foundational Pharm-Tox capabilities at Nvelop, and best practices for managing our growing In Vivo pharmacology program.

This individual will join a multidisciplinary team of scientists and engineers and contribute in a collaborative and fast-paced environment.  The successful candidate will work with projects leads across the organization and external CROs to plan our In Vivo studies. Interface with external Pharm-Tox consultants and drive internal assay development. 

The ideal candidate will have experience designing and supervising nonclinical studies from early discovery to IND-enabling In Vivo studies for development candidates, prepare technical reports, and complete submission-ready documents for regulatory filings (pre-IND, IND, etc.). Drive to execute, experimental rigor and scientific curiosity are key!  We are a small and growing company, the ability to work in a fast-paced environment and adapt to evolving priorities is a must. 
Job Responsibilities:

• Serve as In Vivo Pharmacology lead on project teams by executing experimental and strategic study design, interpreting data independently, and preparing data presentations for program and company meetings.
• Supervise pharmacology studies for appropriate conduct, accuracy, and execution; audit raw data for accuracy, prepare and review draft reports; finalize reports as submission-ready documents for regulatory authorities.
• Work effectively with other groups across R&D, to coordinate timely material production and characterization, help establish consistent quality criteria across our In Vivo pharmacology program.
• Lead efforts to establish a fit for purpose digital infrastructure for our pharmacology portfolio working with our Data Sciences and IT groups.
• Review and contribute to authoring of pharmacology sections of regulatory documents and ensure their quality and accuracy.

Skills and Qualifications: 

• Ph.D. in Pharmacology, Immunology, Molecular Biology or related discipline, with 5 plus years of experience in a biotech or pharmaceutical company.  
• Hands-on laboratory and leadership experience in nonclinical study strategy, In Vivo pharmacology, design, and execution to include data analysis and reporting (viability, efficacy, PK/PD, BioD). 
• Demonstrated management of internal and external (CRO) programs to support drug pharmacology (in vitro, In Vivo), target identification and validation, and critical biomarker generation. 
• Cross-functional team leadership of matrixed teams, including development and mentorship of associates. 
• Ability to work independently as well as part of a team.
• Ability to adapt to a fast-paced environment.

Preferred Qualifications: 

• Hands-on experience with In Vivo evaluation of viral and non-viral delivery vectors in the gene therapy space. 
• Hands-on experience designing and supervising pre-clinical work from early discovery to IND-enabling In Vivo studies, including experience with SEND implementation.

Additional Requirements:

• Full time in-person work is necessary for this laboratory-based position
• We work in facilities that require that all individuals working on-site are vaccinated for COVID-19

Position Title and Salary will be commensurate with Experience

We recognize the value of diversity in our workforce and are committed to building a welcoming and supportive working environment.  We consider all qualified applicants without regard to race, religion, color, gender, age, national origin, sexual orientation, gender identity, partnership status, protected veteran status, disability, or any other status protected by federal, state, or local law.  Individuals who hold legal work authorization applicable to employment in the United States will be considered without regard to citizenship/alienage.

We are not accepting unsolicited resumes from employment agencies for any employment opportunities at this time.