AddressModerna is seeking a Principal Research Associate to work with the Process Development and Protein Science groups. The Principal Research Associate will be responsible for developing bioanalytical enzyme assays, with an emphasis on LC-MS assays and/or plate-based fluorometric/colorimetric assays for enzymes with small-molecule substrates and cell-based assays for enzymes with protein substrates. This individual will work closely with colleagues in Technical Development and the Therapeutic Areas to develop and transfer methods that will ultimately be used in quality-controlled assays to characterize mRNA/LNP drug products. In addition to designing and executing experiments, the candidate will interpret experimental findings and communicate results within and across teams.
Here’s What You’ll Do:
Develop and validate LC-MS-based enzyme activity assays for the detection of small molecules.
Develop and validate plate-based fluorometric/colorimetric assays for the detection of small molecules.
Develop and validate cell-based assays for enzymes with protein substrates.
Document experiments clearly and thoroughly in lab notebooks, protocols, and white papers, to enable effective transfer of assays between groups.
Work closely with therapy area colleagues across Moderna and with Technical Development to transfer methods for use in quality control assays (biochemical and cell-based).
Here’s What You’ll Bring to the Table:
MS in Chemistry, Biochemistry, or Chemical Engineering (or a related field) with 3–5 years industry experience, or BA/BS with 5–10 years industry experience
Experience with LC-MS and LC-MS/MS methods development
Experience with plate-based fluorometric/colorimetric assay development
Preferred: experience with enzyme kinetics
Preferred: experience with cell culture and cell-based assays
Ability to work independently on complex experiments
Ability to collaborate closely with multiple cross-functional project teams
Ability to multi-task to meet technology development and research goals
Strong quantitative analysis skills as well as excellent written and oral communication
Adherence to industry best practices for data documentation
C andidate will be curious in understanding key scientific questions and tailoring analytical assays to answer them, and bold in trying new analytical approaches. Will work collaboratively with multifunctional teams and will be relentless in solving technical problems of separation and detection.
Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:
Highly competitive and inclusive medical, dental and vision coverage options
Flexible Spending Accounts for medical expenses and dependent care expenses
Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
Family care benefits, including subsidized back-up care options and on-demand tutoring
Free premium access to fitness, nutrition, and mindfulness classes
Exclusive preferred pricing on Peloton fitness equipment
Adoption and family-planning benefits
Dedicated care coordination support for our LGBTQ+ community
Generous paid time off, including:
- Vacation, sick time and holidays
- Volunteer time to participate within your community
- D iscretionary year-end shutdown
- Paid sabbatical after 5 years; every 3 years thereafter
401k match and Financial Planning tools
Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
Complimentary concierge service including home services research, travel booking, and entertainment requests
Free parking or subsidized commuter passes
Location-specific perks and extras!
About Moderna
Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world.
By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities.
We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S.
If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.
Moderna is a smoke-free, alcohol-free and drug-free work environment.
Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply!
Moderna is proud to be an equal opportunity workplace and is an affirmative action employer.
Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Moderna is an E-Verify Employer in the United States. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements.
Belonging, Inclusion, and Diversity are critical to the success of our company and our impact on society. We’re focused on attracting, retaining, developing, and advancing our employees and believe that by cultivating diverse experiences, backgrounds, and ideas, we can provide an environment where every employee is able to contribute their best.
Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the Talent Acquisition Partner or contact the Accommodations team at leavesandaccommodations@modernatx.com . (EEO/AAP Employer) #LI-DNI
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