Address
Form of workOverview
We are looking for a Postdoctoral Research Scientist to join Dr. Linda Baker's Lab.
About the Baker Lab: The Baker team is driven to create a future where no child with rare genitourinary disease goes undiagnosed. We are looking for a Postdoctoral Research Scientist to join our Research Group to study the genetic and Molecular basis of urological congenital conditions in a basic science, translational, and clinical research setting.
As a member of this highly collaborative team, your project will lead to advances in pediatric patient care and new scientific discovery. Many projects are focused on characterizing novel genes and variants identified through human whole genome and exome sequencing. We use sequencing analysis as well as a range of molecular tools, including genome editing in animal models and in vitro studies. This is an exciting opportunity for a recent PhD graduate or junior postdoc with a focus on helping the candidate to establish their career as an independent investigator.
About the PI: Linda Baker, MD, a 22-year NIH-funded physician surgeon scientist, recently joined NCH as Co-Director of and Principal Investigator in The Kidney and Urinary Tract Center and as a Clinical Professor of Urology at The Ohio State University. A renowned pediatric urologist and expert in prune belly syndrome (PBS; also known as Eagle-Barrett syndrome), Dr. Baker has met, evaluated and cared for ~185 children with the rare pediatric congenital myopathy affecting the genitourinary tract and abdominal musculature. Her recent research has focused on identifying its genetic basis as a means to understand smooth and skeletal muscle development and function as well as urinary bladder physiology and underactivity states.
Clinically, Dr. Baker specializes in complex genitourinary surgical reconstruction, and she is a national leader in corrective vaginal surgery. With a personalized medicine approach, her research team performs cutting edge DNA testing using next generation sequencing technologies to discover their causes. Her laboratory combines genetically engineered mouse models of pediatric urologic birth defects with clinically valuable human samples.
Beginning in 2001, Dr. Baker created a pediatric urology DNA/tissue repository that currently houses over 4,200 specimens from pediatric urology patients and their families. Overall, Dr. Baker's work contributes to new discoveries for children with PBS, MMIHS, kidney stones, disorders of sexual development, cryptorchidism, hypospadias, cloaca, anorectal malformations, testicular torsion and congenital female vaginal anomalies.
To date, Dr. Baker has authored 23 book chapters and over 120 publications. She has a medical device patent, has held 32 visiting professorships nationally and internationally, and helped coauthor the 2014 AUA Practice Guidelines on cryptorchidism. She currently chairs the Society for Pediatric Urology Research Grants Committee and serves on the American Urological Association (AUA) Practice Guidelines Committee and the Medical Advisory Board of the nonprofit Prune Belly Syndrome Network (PBSN). Previously, she also chaired the AUA Research Grants and Investigator Support Committee.
Responsibilities
Qualifications
We are looking for a Postdoctoral Research Scientist to join Dr. Linda Baker's Lab.
About the Baker Lab: The Baker team is driven to create a future where no child with rare genitourinary disease goes undiagnosed. We are looking for a Postdoctoral Research Scientist to join our Research Group to study the genetic and Molecular basis of urological congenital conditions in a basic science, translational, and clinical research setting.
As a member of this highly collaborative team, your project will lead to advances in pediatric patient care and new scientific discovery. Many projects are focused on characterizing novel genes and variants identified through human whole genome and exome sequencing. We use sequencing analysis as well as a range of molecular tools, including genome editing in animal models and in vitro studies. This is an exciting opportunity for a recent PhD graduate or junior postdoc with a focus on helping the candidate to establish their career as an independent investigator.
About the PI: Linda Baker, MD, a 22-year NIH-funded physician surgeon scientist, recently joined NCH as Co-Director of and Principal Investigator in The Kidney and Urinary Tract Center and as a Clinical Professor of Urology at The Ohio State University. A renowned pediatric urologist and expert in prune belly syndrome (PBS; also known as Eagle-Barrett syndrome), Dr. Baker has met, evaluated and cared for ~185 children with the rare pediatric congenital myopathy affecting the genitourinary tract and abdominal musculature. Her recent research has focused on identifying its genetic basis as a means to understand smooth and skeletal muscle development and function as well as urinary bladder physiology and underactivity states.
Clinically, Dr. Baker specializes in complex genitourinary surgical reconstruction, and she is a national leader in corrective vaginal surgery. With a personalized medicine approach, her research team performs cutting edge DNA testing using next generation sequencing technologies to discover their causes. Her laboratory combines genetically engineered mouse models of pediatric urologic birth defects with clinically valuable human samples.
Beginning in 2001, Dr. Baker created a pediatric urology DNA/tissue repository that currently houses over 4,200 specimens from pediatric urology patients and their families. Overall, Dr. Baker's work contributes to new discoveries for children with PBS, MMIHS, kidney stones, disorders of sexual development, cryptorchidism, hypospadias, cloaca, anorectal malformations, testicular torsion and congenital female vaginal anomalies.
To date, Dr. Baker has authored 23 book chapters and over 120 publications. She has a medical device patent, has held 32 visiting professorships nationally and internationally, and helped coauthor the 2014 AUA Practice Guidelines on cryptorchidism. She currently chairs the Society for Pediatric Urology Research Grants Committee and serves on the American Urological Association (AUA) Practice Guidelines Committee and the Medical Advisory Board of the nonprofit Prune Belly Syndrome Network (PBSN). Previously, she also chaired the AUA Research Grants and Investigator Support Committee.
Responsibilities
- Design experiments and develop protocols required to conduct productive research in a specific scientific area, with guidance from Linda Baker MD and Nathalia Amado, Ph.D (Sr. Research Scientist).
- Design and conduct laboratory-based experiments in cell culture, Molecular Biology, and/or genetically engineered mouse models.
- Critically evaluate and interpret data and determine next steps.
- Work toward research independence by presenting at professional meetings and preparing manuscripts and proposals for funding from external granting agencies.
Qualifications
- PhD or MD in Molecular Biology, Biochemistry, or scientific discipline
- Lab experience at the bench setting
- Necessary technical skills in the appropriate area of research.
