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Form of workJob Description:
Job Summary:
Looking for a self-motivated postdoctoral fellow to join the Center for Psychiatric Genetics of NorthShore University HealthSystem (NUH), academically affiliated with the University of Chicago. This position will be reporting to a PI/Supervisor who is a Professor at the University of Chicago. The lab's research focus is on using patient-specific induced pluripotent stem cells (iPSC)-derived neurons and brain organoids models to study the molecular and neurobiological basis of neuropsychiatric and neurodegenerative disorders (Forrest MP. et a., Cell Stem Cell. 2017; Zhang S. et al., Science. 2020; Kozlova A. et al., Am J Hum Genet 2022 ). The laboratory work will involve iPSC neural modeling, single cell RNA-seq and ATAC-seq, CRISPR/Cas9 gene editing, CRISPRi/a for gene perturbation, scaled morphological and electrophysiological analyses of neurons and brain organoids. The candidate will preferentially perform both experimental and computational work with the assistance of other research associates/assistants, but focusing on lab or computation would also be acceptable. For a candidate focusing on computation, he/she is expected to implement and/or develop computation tools for analyzing multi-omics (scRNA-seq/ATAC-seq, genomics, lipidomics, etc.) data to understand the causal genes/networks of neuropsychiatric and neurodegenerative disorders. This position reports directly to the PI. This is a full-time position and is benefits eligible.
Essential Job Functions:
1) Take a lead in work involved in NIH funded projects.
2) Work independently under supervision of the PI.
3) Ability to prepare scientific manuscripts for publication.
4) Capable of identifying problems that may adversely affect experiment or reporting of results and of taking corrective action or notifying appropriate supervisory personnel.
5) Ability to assist in submission of research grant applications and periodic progress reports
Minimum Formal Education Required:
PhD in Molecular/Cellular Biology, Computational biology/Bioinformatics, Neuroscience or other related discipline.
License and/or Certification Required: no
Minimum Length and Nature of Experience Required:
Previous research experience from PhD training related to molecular/cellular biology, neuroscience, genomics, or computational biology/bioinformatics.
Special Knowledge and Skills Required:
Physical Demands/Environmental Conditions: none
Equipment Utilized within the Scope of the Position:
Computers, cell culture hoods, confocal microscopes, DNA sequencing instrument, qPCR instrument.
Benefits:
NorthShore - Edward-Elmhurst Health is a fully integrated healthcare delivery system committed to providing access to quality, vibrant, community-connected care, serving an area of more than 4.2 million residents across six northeast Illinois counties. Our more than 25,000 team members and more than 6,000 physicians aim to deliver transformative patient experiences and expert care close to home across more than 300 ambulatory locations and eight acute care hospitals - Edward (Naperville), Elmhurst, Evanston, Glenbrook (Glenview), Highland Park, Northwest Community (Arlington Heights) Skokie and Swedish (Chicago) - all recognized as Magnet hospitals for nursing excellence. Located in Naperville, Linden Oaks Behavioral Health, provides for the mental health needs of area residents. For more information, visit NorthShore.org, SwedishCovenant.org, NCH.org and EEHealth.org.
When you work for NorthShore - Edward-Elmhurst Health, you will be part of an organization that encourages its employees to achieve career goals and maximize their professional potential.
Please explore our website (www.northshore.org) to better understand how NorthShore - Edward-Elmhurst Health delivers on its mission to "help everyone in our communities be their best".
NorthShore - Edward-Elmhurst Health is committed to working with and providing reasonable accommodation to individuals with disabilities. Please refer to the main career page for more information.
Diversity, equity and inclusion is at the core of who we are; being there for our patients and each other with compassion, respect and empathy. We believe that our strength resides in our differences and in connecting our best to provide community-connected healthcare for all.
EOE: Race/Color/Sex/Sexual Orientation/ Gender Identity/Religion/National Origin/Disability/Vets, VEVRRA Federal Contractor.
#ZRNC
#LI-JR2
Overall Qualifications:
Doctorate, MD, PHD (Required)
Job Summary:
Looking for a self-motivated postdoctoral fellow to join the Center for Psychiatric Genetics of NorthShore University HealthSystem (NUH), academically affiliated with the University of Chicago. This position will be reporting to a PI/Supervisor who is a Professor at the University of Chicago. The lab's research focus is on using patient-specific induced pluripotent stem cells (iPSC)-derived neurons and brain organoids models to study the molecular and neurobiological basis of neuropsychiatric and neurodegenerative disorders (Forrest MP. et a., Cell Stem Cell. 2017; Zhang S. et al., Science. 2020; Kozlova A. et al., Am J Hum Genet 2022 ). The laboratory work will involve iPSC neural modeling, single cell RNA-seq and ATAC-seq, CRISPR/Cas9 gene editing, CRISPRi/a for gene perturbation, scaled morphological and electrophysiological analyses of neurons and brain organoids. The candidate will preferentially perform both experimental and computational work with the assistance of other research associates/assistants, but focusing on lab or computation would also be acceptable. For a candidate focusing on computation, he/she is expected to implement and/or develop computation tools for analyzing multi-omics (scRNA-seq/ATAC-seq, genomics, lipidomics, etc.) data to understand the causal genes/networks of neuropsychiatric and neurodegenerative disorders. This position reports directly to the PI. This is a full-time position and is benefits eligible.
Essential Job Functions:
1) Take a lead in work involved in NIH funded projects.
2) Work independently under supervision of the PI.
3) Ability to prepare scientific manuscripts for publication.
4) Capable of identifying problems that may adversely affect experiment or reporting of results and of taking corrective action or notifying appropriate supervisory personnel.
5) Ability to assist in submission of research grant applications and periodic progress reports
Minimum Formal Education Required:
PhD in Molecular/Cellular Biology, Computational biology/Bioinformatics, Neuroscience or other related discipline.
License and/or Certification Required: no
Minimum Length and Nature of Experience Required:
Previous research experience from PhD training related to molecular/cellular biology, neuroscience, genomics, or computational biology/bioinformatics.
Special Knowledge and Skills Required:
- Knowledge of molecular/cellular biology, neuroscience, genomics, or computational biology/bioinformatics.
- Ability to prepare manuscript for publications in peer-reviewed journals and to develop scientific proposals.
- Experience with stem cell culture and neuroscience research or capability of analyzing large genomic datasets is preferred
Physical Demands/Environmental Conditions: none
Equipment Utilized within the Scope of the Position:
Computers, cell culture hoods, confocal microscopes, DNA sequencing instrument, qPCR instrument.
Benefits:
- Career Pathways to Promote Professional Growth and Development
- Various Medical, Dental, Pet and Vision options, including Domestic Partner Coverage
- Tuition Reimbursement
- Free Parking
- Wellness Program Savings Plan
- Health Savings Account Options
- Retirement Options with Company Match
- Paid Time Off and Holiday Pay
- Community Involvement Opportunities
- Visa Sponsorship Available (Nursing and Lab roles)
NorthShore - Edward-Elmhurst Health is a fully integrated healthcare delivery system committed to providing access to quality, vibrant, community-connected care, serving an area of more than 4.2 million residents across six northeast Illinois counties. Our more than 25,000 team members and more than 6,000 physicians aim to deliver transformative patient experiences and expert care close to home across more than 300 ambulatory locations and eight acute care hospitals - Edward (Naperville), Elmhurst, Evanston, Glenbrook (Glenview), Highland Park, Northwest Community (Arlington Heights) Skokie and Swedish (Chicago) - all recognized as Magnet hospitals for nursing excellence. Located in Naperville, Linden Oaks Behavioral Health, provides for the mental health needs of area residents. For more information, visit NorthShore.org, SwedishCovenant.org, NCH.org and EEHealth.org.
When you work for NorthShore - Edward-Elmhurst Health, you will be part of an organization that encourages its employees to achieve career goals and maximize their professional potential.
Please explore our website (www.northshore.org) to better understand how NorthShore - Edward-Elmhurst Health delivers on its mission to "help everyone in our communities be their best".
NorthShore - Edward-Elmhurst Health is committed to working with and providing reasonable accommodation to individuals with disabilities. Please refer to the main career page for more information.
Diversity, equity and inclusion is at the core of who we are; being there for our patients and each other with compassion, respect and empathy. We believe that our strength resides in our differences and in connecting our best to provide community-connected healthcare for all.
EOE: Race/Color/Sex/Sexual Orientation/ Gender Identity/Religion/National Origin/Disability/Vets, VEVRRA Federal Contractor.
#ZRNC
#LI-JR2
Overall Qualifications:
Doctorate, MD, PHD (Required)
