Investigator/Biostatistician

Investigator/Biostatistician

The Center for Clinical Investigation (CCI) is designed to provide infrastructure support to the investigative community, leading to a more effective and robust clinical research enterprise at Brigham and Women’s Hospital.

This position involves project management for the statistical analyses and programming of clinical trials from small investigator initiated studies to large scale international clinical trials. For the projects in which the successful candidate participates, the person will become an integral part of the research team from research development to protocol design to pre-designed statistical plan to analyses to manuscript preparation. Qualified candidates will have advanced formal training in statistics or biostatistics including design and analysis of observational and experimental studies, and strong statistical computing skills. The incumbent will work in collaboration with various clinical and research groups within Brigham and Women’s Hospital to develop statistical analyses for investigational protocols with a focus on genetic protocols. The highly-qualified Biostatistician will support clinical investigation with a focus on genetic studies, including design and analysis of clinical studies, estimate sample size and power, interpret results and write statistical sections of papers and grants collaboration with investigators affiliated with Harvard Medical School, grant and protocol development and review, and teaching and mentoring of junior investigators.

1. Work with investigators and other research personnel independently or with minimal supervision. Possess a solid understanding of the purpose, objectives and goals of each trial.

2. Collaborate with investigators to develop and perform statistical analyses (including planning, programming, analysis, interpretation and writing of results) for investigational protocols, subgroup and post-hoc projects and registry databases ending with preparation of manuscripts, abstracts and presentations at scientific meetings.

3. Informal teaching and clear communication with investigators regarding project statistics.

4. Design studies, perform power analysis and sample size justification.

5. Ability to independently derive clinical trial databases and perform validation analyses of ongoing clinical trials.

6. Contribute statistical sections and statistical guidance for grants and protocols. Determine and/or verify correct statistical testing to be performed in each analysis request.

7. Analyze data and write results. Rearranges data in a format that allows for accurate use as well as possible integration and pooling across trials.

8. Write methods sections

9. Meet deadlines.

10. Assure the maintenance of an up-to-date electronic archive recording data requests, statistical analyses, results, and data transmissions performed.

11. Administrative tasks such as tracking hours for projects.

12. Participate and contribute at research meetings.

13. Maintain department service standards as outlined in the BWH Code of Conduct

14. Other duties as requested by Biostatistics Director. These may include web page development, utility programs, documentation, and/or teaching.

Office setting.Occasionally flexible hours may be required to meet deadlines.

• PhD prepared in bio-statistics or a related field.

• Needs to meet the requirements for appointment as a faculty member at Harvard Medical school, if applicable.

• High proficiency in statistical computing.

• Required: Data analysis, study design, grant writing.

• Proficiency in software development (SAS, R, Python, Matlab) and developing machine learning and predictive models.

• Desired: Clinical trials, case-control and cohort studies, statistical genetics, protocol monitoring, hierarchical, longitudinal, survival, categorical, nonlinear, and epidemiology.

• Experience with programming in SAS, R and other statistical software and working with various database structures are crucial components of this position.

• Ability to work independently as well as part of a team

• Possess strong analytical skills

• Ability to prioritize assignments, multi-task, make decisions based upon sound principles, and independently problem solve.

• Ability to draft plans to resolve inaccuracies or other problematic situations.

• Excellent verbal and written communication skills

• Detail and process oriented

• Ability to manage multiple projects simultaneously, including both long-term and short-term projects

• Ability to develop novel ways to coordinate, manage and report data if required by new trials.

• Demonstrated sound independent judgment and competencies in clinical research.

• A high level of patient and data confidentiality and security must be maintained.

• United States Citizenship and Immigration Services rules concerning identity and right to work in the United States

• Multi-state criminal background checks

• Review of the Medicare Sanctions and Exclusions List

• Pre-employment health and drug screening and annual compliance with the Influenza Vaccination Policy

BWH is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.