Head Of Sequencing / Senior Scientist

This is an exciting opportunity to join a fast-paced, growing Focused Research Organization (FRO) startup (currently in stealth). Head of Sequencing will conduct NGS-based experimental research and contribute to novel assay development in a dynamic, interdisciplinary environment. The successful candidate will develop high-throughput workflows and generate datasets from adaptive immune cells. Head of Sequencing will work closely with other top-tier experimental and computational scientists to create groundbreaking new insights into adaptive immunity. 

Responsibilities

• Design, plan, and execute NGS-based assays in coordination with interdisciplinary science teams.
• Prepare DNA and RNA libraries from immune cells.
• Maintain high standards for sequencing quality and throughput by rigorously performing in-house QC checks and remaining current with industry best practices.
• Establish and optimize workflows, write and maintain SOPs for NGS assays, maintain sequencer uptime, and manage reagent inventory. 
• Contribute to the development of novel NGS and multiomics assays and research, inclusive of experimental design.
• Collaborate effectively with computational, molecular biology, and translational researchers.
• Oversee junior research staff.
• Demonstrate a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others.

Key Qualifications

• BS, MS, or PhD in biomedical engineering, genetics, immunology or related field that relies on next-generation sequencing applications.
• High proficiency with nucleic acid preparation from eukaryotic sources, preferably adaptive immune cells.
• Proven track record of custom library-preparation development for next-generation sequencing.
• Expertise with scRNA-seq and other NGS approaches.
• Strong organizational, time management, and communication skills.

Advanced Qualifications (experience in the following is preferred, but not required)

• Prior experience in adaptive immunity research.
• Familiarity with diverse next-generation sequencing technologies such as Pacific Biosciences, Oxford Nanopore, and/or Ion Torrent.
• Experience with single-cell multiomics techniques (eg, CITE-seq, LIBRA-seq), long-reads, and/or proteomic antibody sequencing (Ab-seq).
• Familiarity with diverse microfluidics, microwell, and microfluidics-free platforms.
• Experience with liquid handling automation for sequencing library preparation.
• Proficiency in custom protocol development.
• Experience with sequencing and/or multi omic assay development.
• Competence in R and/or Python (Scanpy, Seurat).
• Management experience (inclusive of research assistants or graduate students).

We Offer

• Competitive compensation: $100,000 - $140,000 a year (salary commensurate with experience)
• Excellent medical, dental, and vision insurance 
• Generous time off + paid holidays
• A supportive environment to learn and develop new skills
• An opportunity to participate in high-impact, fast-paced, cutting-edge, collaborative team science; contribute to curing disease; and work with leading experts from different fields
• Exciting location in the Soho area of Manhattan

We aim to help fill a structural gap in today's R&D system. We enable fundamental research that requires unusual levels of scale and coordination yet is not rapidly monetizable by industry. We're bringing together top talent from academia, industry, and startups to build a new model for innovative R&D. As an incubator within the Schmidt Futures Network, we identify high-impact scientific or technical research and development opportunities, ultimately defining and launching these projects as Focused Research Organizations.

 

We are an Equal Employment Opportunity employer that proudly pursues and hires a diverse workforce. We do not make hiring or employment decisions on the basis of race, color, religion or religious belief, ethnic or national origin, nationality, sex, gender, gender-identity, sexual orientation, disability, age, military or veteran status, or any other characteristic protected by applicable local, state, or federal law or company policy. We strive for a healthy and safe workplace and strictly prohibit harassment of any kind.