[Based In China] Car-T Process Development (Multiple Levels)

Legend Biotech is seeking CAR-T Process Development (Multiple Levels) as part of the R&D team Based inNanjing, China. 

Key Responsibilities  

• Lead a discovery research team developing innovative ways to manufacture cell products for clinical trials.
• Subject matter expert in CAR-T cell Process Development and manufacturing.
• Execute research timelines to meet program and corporate objectives.
• Design, execute, and interpret Process Development study data to understand the mechanism-of-action and play an active role in subsequent scientific discussions to drive decisions.
• Write and review protocols, SOPs, technical reports, regulatory documents, and memos to summarize experiments and investigations.
• Partner with internal cross-functional team members to facilitate technical assessment, technical transfer, and IND filing.
• Closely mentor scientists to further develop talents within the group.
• Other duties will be assigned, as necessary.

• Ph.D. in Cell Biology, Immunology, Genetic Engineering , or related discipline.
• Minimum of 6+ years relevant pharmaceutical industry/academic experience post-graduation.
• Extensive hands-on experience with CRSIPR- genome engineering in multiple cell types.
• Independently design constructs and sgRNA for KO/KI through non-viral gene transfer technologies (EP, LNP) or viral transfer technologies (LVV, RVV, VLP).
• Profound skills in analytical methods including but not limited to flow cytometry, real-time PCR, off-target evaluation, NGS, ddPCR.
• Extensive experience in CAR-T, CAR-T, or CAR-NK cell immunotherapies, including cell culture, immune cell activation, expansion, viral transduction or /and non-viral gene transfer, in vitro & in vivo characterization.
• Team management experience is preferred.
• Excellent communication skills both in English and Chinese, detail-oriented organization skills, and team collaboration skills.
• Strong ability to analyze data, report data, present findings to management is required.
• Ability to manage priorities and make decisions in a fast-paced environment to make sure deliverables are achieved in a timely fashion.
• A strong track record of scientific accomplishments, including first-author publications, patent applications, and/or presentations at major national meetings, is required.
• Occasional domestic or international travel required.

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