Associate Director, Clinical Digital Pathology

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.

About the role:

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as an Associate Director, Clinical Pathology in our Cambridge, Massachusetts office.

• The Biomarker and Bioanalytical Science & Technologies (BST) department at Takeda is seeking a strong scientific and strategic leader to serve as a resident pathology/IHC assay expert to support implementation of pathology biomarkers in clinical development programs across therapeutic areas and modalities.
• The candidate will work closely with the translational scientists and key stakeholders across Takeda to support implementation of fit-for purpose pathology/IHC biomarkers and delivery of key assays and data to clinical trials to facilitate decision making.
• The candidate will advise teams on best practices and biomarker assays/technologies, as well as investigating novel technologies for clinical readiness and implementing as necessary.
• Maintain and enhance image management system and methodologies for routine image analysis as well as advance machine-based learning algorithms for feature extraction of histological images.

How you will contribute:

ACCOUNTABILITIES

• As a BST pathology subject matter expert, participate in program team meetings (e.g. clinical and translational subteams) and provide insight and support in general histology, IHC, ISH, imaging and analysis, and other tissue-based assays.
• Evaluate, select, and oversee external labs and vendors to ensure successful design and execution of clinical assays, including validation, longitudinal performance, data quality, and timely delivery.
• Develop and present biomarker results to translational teams, and collaborate with translational biomarker lead and other key stakeholders.
• Collaborate with translational sciences, statisticians, computational biology and other poartners to analyze and interpret data in the context with other clinical data.
• Lead development of innovative approaches to new assays based on emerging scientific insights, new technologies and/or program needs.
• Other responsibilities include serving as a scientific lead on diligence of cutting-edge technologies, establishing external partnerships (e.g. scientific leaders, KOLs, academic partners, CROs, and health authorities), mentoring other scientists, and actively publishing/presenting in the external scientific community.

DIMENSIONS AND ASPECTS

Technical/Functional (Line) Expertise

• Strong scientific background and experience with assay development and validation across technology platforms in pathology, especially those that are clinically amenable (e.g. IHC, ISH, IF, and multiplex assays).
• Strong understanding of and experience in Digital Pathology technologies and workflows including image analysis software such as Visiopharm and/or HALO.
• Demonstrates well-developed knowledge of other disciplines / departments and how they function together.
• Demonstrates exceptional project management skills.

Minimum Requirements/Qualifications:

• A PhD, MD, or MD/PhD in pathology, immunology, or related discipline with at least 8 years of relevant experience beyond post-doctoral training, including at least 4 years of industry experience.
• Strong scientific background and experience with assay development and validation across technology platforms in pathology, especially those that are clinically amenable (e.g. IHC, ISH, IF, and multiplex assays).
• Strong understanding of and experience in Digital Pathology technologies and workflows including image analysis software such as Visiopharm and/or HALO.
• Experience with advanced analysis tools such as deep learning algorithms or AI and/or other technologies such as genomics, spatial transcriptomics, etc a plus.
• Disease knowledge and experience in oncology and/or gastroenterology.
• Experience with outsourcing and working with external partners to develop/transfer assays and to oversee data generation/analysis and delivery of high quality data within expected timelines.
• Familiarity with clinical documents and processes, i.e. clinical protocols, informed consent forms, laboratory manuals, central lab logistics, etc.
• Strong written and oral communication skills, ability to influence and inspire, takes initiative yet team-oriented and collaborative, and able to navigate and be effective in large matrixed environments.
• Prior leadership and mentoring experience a plus.

What Takeda can offer you:

• Comprehensive Healthcare: Medical, Dental, and Vision
• Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan
• Health & Wellness programs including onsite flu shots and health screenings
• Generous time off for vacation and the option to purchase additional vacation days
• Community Outreach Programs and company match of charitable contributions
• Family Planning Support
• Flexible Work Paths
• Tuition reimbursement

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

This position is currently classified as "hybrid" in accordance with Takeda's Hybrid and Remote Work policy.

LOCATION:

• The role is based in Cambridge, MA

Base Salary Range: $143,500-$205,000. Employees may also be eligible for Short Term and Long-Term Incentive benefits. Employees are eligible to participate in Medical, Dental, Vision, Life Insurance, 401(k), Charitable Contribution Match, Holidays, Personal Days & Vacation, Tuition Reimbursement Program and Paid Volunteer Time Off.

The final salary offered for this position may take into account a number of factors including, but not limited to, location, skills, education, and experience.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.