POSITION SUMMARY:
ESSENTIAL DUTIES AND RESPONSIBILITIES:
- Proactively evaluates the clinical implications of safety data from pre-clinical studies, clinical studies, literature, and other information sources in order to predict/establish the safety profile of compounds in clinical development
- Supports and provides oversight for medical review of case narratives for medical content, accuracy, and signal detection
- Interprets aggregate safety data for periodic reports and evaluating for potential new signals
- Leads signal detection, signal evaluation, data analysis, and benefit-risk evaluation for assigned compounds, including oversight of contractor Safety Physicians as applicable
- Supports VP with implementation of risk management and mitigation activities, including medical and safety leadership for Risk Management Plans
- Writes individual case assessments and evaluates aggregate safety data for periodic reports
- Provides medical input into identification and utilization of appropriate sources of information and database searches to retrieve relevant data for evaluation of signals
- Offers medical judgment on complex safety issues
- Presents safety data to Data Monitoring Committees or assigned products and internal Safety Assessment Committees
- Provides vendor oversight for assigned products where applicable (e.g., CROs contracted for safety reporting)
- Participates in cross-functional project teams including Clinical Trial Study Teams; communicates across organizational levels and functions
- Contributes to the maintenance of the pharmacovigilance system and processes including partnership with Safety Analytics on Rx Logix tool
- Participates in SOP updates, audits, and inspection readiness
- Writes/updates core safety information for assigned projects in collaboration with Safety Operations
- Writes/reviews and provides technical input for the safety sections of regulatory documents for assigned projects including protocols and periodic reports
- Supports preparation of regulatory authority and local/regional ethics board correspondence
- Supports preparation for external meetings with Health Authorities
- Guides and/or trains external personnel/parties involved in Company’s clinical studies where applicable to Medical Safety
- Collaborates effectively in cross-functional and cross-cultural project teams and works with external providers
- Maintain clinical and technical expertise in the therapeutic areas, i.e., through review of scientific journals, attendance at scientific and key technical meetings, etc.
- May participate/present safety material to Company and Investigator’s meetings and other medical meetings
- Participates in selection and bidding activities for vendors and contractors
- Ensures that safety science practices comply with Good Vigilance/ Pharmacovigilance Practices as well as internal safety processes, and maintains up-to-date knowledge of regional regulatory guidances
- Willing to participate in workshops and trainings to build skills and knowledge of drug development in pediatric and rare disease
- Managerial responsibilities as necessary
- Medical Degree (e.g., MD, MBBS, DO) required
- Training in epidemiology, pharmacology or MPH a plus
- 8+ years’ experience as a Medical Safety Physician or similar experience with safety oversight activities related to clinical trials in academia or industry
- Experience as a leader, mentor or people manager is preferred
- Foundational knowledge of clinical research and global regulatory requirements, and practices governing expedited and periodic safety reporting, signal generation, safety evaluation, and risk management activities, including regulations governing pharmacovigilance
- Strong skills in the management of safety information originating from both clinical development and post-marketing sources
- Working knowledge of industry standard pharmacovigilance databases, particularly Argus
- Strong leadership skills and ability to communicate with individuals at all levels
- Excellent oral and written communication skills
- Excellent analytical skills, detail-oriented, and ability to work independently
- Ability to exercise creativity and judgment