Scientist - Immunoassay And Biomarker Development

POSITION SUMMARY:

The Scientist – Immunoassay and Biomarker Development’s primary focus is on immunoassay development, screening, and Biomarker projects.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

• Assist in ligand binding assay method development (MSD, ELISA) and provide technique and application support for immunoassays transferred to downstream users.
• Test antibody quality for purity (SDS-PAGE), specificity (Western Blot, ELISA), and concentration (Nanodrop, BCA).
• Conduct assay performance validation.
• Conduct compound screening utilizing the developed assays.
• Develop pharmacodynamic biomarker assays to support internal clinical development.
• Perform protein analysis (SDS/native-PAGE, Western Blot, and Immunoprecipitation).
• Develop experiment protocols and prepare SOPs.
• Perform and manage cell culture experiments for MOA, PD biomarker mechanistic insight, as well as biomarker assessment.
• Perform laboratory experiments carefully and troubleshoot to solve problems.
• Meticulously document experiment results in laboratory notebooks and databases timely.
• Analyze, summarize, and present experimental results to managers and other team members.
• Prepare experiment and project reports as required.
• Order and stock laboratory supplies for a continuous and consistent workflow.
• Other duties, as assigned.

REQUIREMENTS:

• Requires a PhD (1-3 years’ experience) or MS (4-7 years) in biology/biochemistry/chemistry/immunology.
• Knowledge and prior experience with protein analytical methods, such as ELISA, Protein concentration assays, SDS-PAGE, Western Blot and mass spectrometry (a plus).
• Prior experience managing cell culture experiments for MOA and Biomarker assessment.
• Qualified applicants must have good pipetting skills, be analytical and flexible.