Address
Form of workScientist II, Bioinformatics
Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas!
Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com.
About Astellas Gene Therapies
Astellas Gene Therapies is an Astellas Center of Excellence developing genetic medicines for patients with rare, life-threatening diseases. Based on our innovative approach to developing genetic medicines, as well as our industry-leading internal manufacturing capability and expertise, we have become the Astellas Center of Excellence for their newly-created Genetic Regulation Focus Area. We are currently exploring three gene therapy modalities: gene replacement, exon skipping gene therapy, and vectorized RNA knockdown, with plans to expand our focus and geographic reach under Astellas. We are based in San Francisco, with manufacturing and laboratory facilities in South San Francisco and Sanford, North Carolina. For more information, please visit our website: www.astellasgenetherapies.com.
Responsibilities
- Research and implement efficient AI/machine learning (ML) algorithms and feature exploration methods
- Develop worfklows from existing algorithms, or modify bioinformatics methods to analyze next generation sequencing (NGS) data, including but not limited to long-read sequencing, RNA-seq, whole genome sequencing (WGS), scRNA-seq.
- Develop and implement novel algorithm and methods for NGS data types to meet R&D objectives, and the demonstration of the validity of the methods through prototypes and benchmarking using appropriate controls.
- Run, maintain, and add to bioinformatics methods and workflows for analysis of large-scale data using AWS cloud compute
- Work within the bioinformatics team to review and test code
- Stay current of the latest advancements in bioinformatics and apply innovative approaches to research projects.
Location(s)CA, San Francisco (1CNS0100)
Requirements
Required Qualifications
- PhD in Computer Science, Bioinformatics, Molecular and Cell Biology or related disciplines.
- 4+ years of hands-on experience with gene expression/NGS data analysis using AI/ML
- Expertise with common NGS visualization and processing tools (e.g., IGV, samtools, DESeq2).
- Proficiency in Linux/Bash, Python and R.
- Familiarity with Cloud
- Demonstrated experience with version control tools (e.g., git).
- Support routine data management for clinical next-generation sequencing projects (i.e. data transfer, analysis, storage, and retrieval)
- Proven ability to work in cross-functional teams as a strong team player as well as independently.
- Successful history and the ability to handle several fast-paced projects concurrently.
- Excellent communication, writing and presentation skills to technical and non-technical audiences.
Preferred Qualifications
- Experience working with viruses, especially Adeno-Associated Virus (AAV)
- Industry experience
Salary Range: $112,500 - $150,000 (NOTE: Final salary could be more or less, based on
experience)
Benefits:
- Medical, Dental and Vision Insurance
- Generous Paid Time Off options, including Vacation, Sick time, plus national holidays including Heritage Days, and Summer and Winter Breaks
- 401(k) match and annual company contribution
- Company paid life insurance
- Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions
- Long Term Incentive Plan for eligible positions
- Referral bonus program
All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, protected veteran status, or on the basis of disability.
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