Scientist Bioscience in vivo, Early Respiratory and Immunology

Location: Waltham/Boston, MA

AstraZeneca is a global, science-driven biopharmaceutical company. We are dedicated to discovering, developing, and delivering innovative, relevant medicines and healthcare solutions that enrich the lives of patients. The vision of AstraZeneca Early Respiratory & Immunology (Early R&I) is centered on delivering life-changing products that advance world health and help fight and cure disease. Early R&I is one of three main therapeutic research areas within AstraZeneca that deliver candidate drugs into late-stage clinical development. We are building new capabilities to support our growth in immunology and autoimmune diseases, and we have an exciting opportunity for an in vivo scientist looking to help bring new medicines to patients.

As a part of a growing in vivo Bioscience team within the Early R&I department, we are seeking a highly motivated research associate with diverse laboratory skills to join our collaborative team. This candidate would ideally have experience in immunology or related discipline. This is a lab-based position. The role will initially be based in Waltham, MA within AstraZeneca’s brand new laboratories where you will follow the science to help drive innovation and advance medicine to help improve patient lives. In 2026 we will be located at the new innovative facilities in Kendall Square Cambridge.

Main Duties and Responsibilities

In this role, you will be an experimental scientist within Early Respiratory and Immunology Department focusing on developing therapeutics for the treatment of immune and autoimmune diseases such as SLE, colitis and arthritis using mouse models. You will generate preclinical and translational data in support of key portfolio programs and drive technical excellence in bioscience research. Expertise in in vivo mouse models, in flow cytometry, multiplex cytokine read-outs, qPCR is essential. The role will sometimes involve implementing protocols over timelines that extend outside of normal working patterns.

Accountabilities and responsibilities:

• Excellent hands-on in vivo skills and the ability to independently run disease and mechanistic models, including administering candidate drugs and collecting a range biological samples.
• Responsible for maintaining the highest standards of animal welfare and ethical compliance as well as data integrity
• Depending on experience you may be assigned as in vivo lead for studies supporting pre-clinical discovery and early development projects.
• Design and develop disease-relevant in vivo models and biomarkers
• Contribute to the evaluation and interpretation of primary data as well as writing reports and summaries
• Supporting drug discovery projects to meet their objectives by acting as an effective and creative team member

Essential requirements

• PhD in relevant degree in biology, immunology or relevant discipline and 2+ years post-doc or a master’s degree and 5+ years of relevant industry experience with extensive proven track record of in vivo work required.
• Practical In vivo experience and experimental skills in the use of animal models and tissue processing.
• Experience in molecular and cellular biology techniques including RT-PCR, ELISA, flow cytometry and assay development.
• Good understanding of pharmacology, physiology and Immunology.
• Analytical skills related to in vivo research and data analysis.
• Good written and oral communication skills in English.
• As highly motivated, independent scientist - be able to work effectively as part of a team and develop ideas by incorporating the views of others.
• Able to communicate effectively across language, cultural, or other barriers.
• Understanding of statistical methods, quality control including data reporting and archiving.

Desirable requirements

• Immunology/autoimmune disease knowledge, including target and mechanism knowledge (e.g. SLE, arthritis, IBD)

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering groundbreaking methods and bringing unexpected teams together. Interested? Come and join our journey.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.”

So, what’s next!

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

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