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Form of workJob Description
Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
Arrowhead is seeking an industry experienced and highly motivated scientist to lead a discovery biology team at its new research and development facility in San Diego, CA. This is an ideal position for an individual with a strong background in drug development who enjoys leading other scientists in a team-oriented, fast-paced, and highly cross-disciplinary environment. The Director/Sr. Director of Discovery Pharmacology will drive the strategic planning and execution of drug discovery programs from target validation through clinical candidate selection. The successful candidate will work collaboratively with Translational Genetics and Discovery Chemistry to identify new therapeutic areas for application of the TRiM platform technology and develop appropriate in vitro and in vivo models for proof of concept studies and drug discovery activities.
Responsibilities
- Identify potential disease targets for treatment via RNA interference
- Lead project coordination, experimental design and execution, and data analysis for identifying and developing new therapies based on RNA interference
- Lead program-related in vitro and in vivo functional assay development, including introducing and implementing new laboratory techniques
- Collaborate to solve technical challenges arising in the Company's development programs within and across the Company's various drug discovery teams
- Manage the work of a team of scientists, while working closely with other research groups and senior managers
- Coordinate efforts with existing chemistry, biology, toxicology, and program management functional areas
- Keep abreast of competitive advances in relevant disease areas as well as advances across RNAi landscape
Requirements:
- Ph.D. in Pharmacology, Cell Biology, Molecular Biology, Biochemistry, or a related discipline
- Minimum of 10 years of post-PhD hands on experience in early drug development research in an industrial setting
- Track record of successful management of scientists and associates
- Expertise in cell and molecular biology, biochemistry and pharmacology necessary to lead biology innovation across multiple disease areas
- Excellent problem-solving skills in experimental design, data analysis and interpretation
- Exceptional verbal and written communication skills
- Proven ability to translate cutting edge research into a drug development program
- Ability to remain productive, organized and flexible in a fluid and fast-paced environment
Preferred:
- Experience with methods and technologies in drug development, including target identification and validation, in vitro cell-based assays, immunoassays, flow cytometry and microscopy
- Expertise in immunology, oncology, or cardiovascular disease
- Experience with in vivo disease models
- Experience with oligonucleotide therapeutics
- Experience in gene expression analysis
Arrowhead provides competitive salaries and an excellent benefit package.
All applicants must have authorization to work in the US for a company.
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