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SalaryWe engineer stem cell transplants that shield healthy cells from targeted therapies
Targeted therapies work by attacking cells that express particular proteins on their surface. Unfortunately, both diseased and healthy cells often express the same proteins, resulting in collateral damage to healthy cells.
At Vor Bio, we engineer hematopoietic stem cells (HSCs) to lack a biologically redundant target protein, then transplant these cells into the patient.
These eHSCs give rise to generations of new healthy blood cells that are effectively shielded from targeted therapies so that only the remaining cancer cells are killed. We are also developing our own CAR-T cell therapy using T cells from the same healthy donor who could potentially provide HSCs for our shielded stem cell transplant and thereby, avoid issues of donor-mismatch. We believe our CAR-T cell therapy may enable more potent and durable responses post-transplant.
Vor Bio is aiming to cure blood cancers through our novel platform combining HSC biology, genome engineering, and targeted therapies to unlock treatment options previously unavailable to patients. Come be a part of a passionate team striving to collaboratively develop a groundbreaking approach to cancer treatment, one of medicine's greatest challenges.
What we value in our fellow Voracians
Passion: Enthusiastically driving our science toward innovative medicines
Fellowship: Fostering genuine bonds of collaboration and mentorship
Humility: Acting selflessly by putting the collective mission first
Who we are looking for:
Vor Bio is looking for a highly motivated Co-op to join our growing Clinical MSAT & Tech Transfer team. The successful candidate will be integral in supporting manufacturing processes for our novel therapies. The position requires enthusiasm, passion, attention to detail, and a desire to create new medicines for patients. This team is responsible for translating cell therapy production methods from process development into reliable and optimized processes to be performed in clinical manufacturing in addition to supporting on-going clinical manufacturing.
Key areas of responsibility:
- Critical data management of clinical manufacturing results and process trending
- Support internal and external manufacturing of clinical products
- Support investigations, deviations, and CAPA closure and reconciliation
- Track and trending of quality events to support internal manufacturing excellence
- Draft and revise SOPs and Manufacturing Batch Records to support continuous improvement
- Work closely with stakeholders across departments, including Process and Analytical Development, Manufacturing, Supply Chain, Quality Assurance, and Quality Control
Qualifications:
- BS/MS Coursework and/or co-op experience in Biology, Biotechnology, Chemical Engineering or related field
- Exposure to mammalian cell culture is preferred
- Exposure to cell isolation is preferred
- Understanding of cGMP requirements and previous experience in technology transfer is preferred
- Ability to work collaboratively in a team environment and to consistently deliver exceptional results
- Excellent problem-solving and communication skills
- Structured, creative, and action-oriented mindset
- Excellent oral and written communication skills
- Track record of intellectually challenging oneself to enhance scientific capabilities
