The summer internship in downstream process development will give insight into the manufacturing process for complex biomolecules along with hands-on production experience using bioprocessing techniques - including bioreactors, depth filtration, tangential flow filtration, and fast protein liquid chromatography. The intern will not only have the opportunity to interact with the downstream team, but also the upstream, analytical development, and formulation teams to learn how drug products are developed safely, cost-effectively, and efficiently from lab scale (≤10L) to commercial scale (>1000L).
In addition, the intern will be exposed to leading-edge development approaches and technologies used to overcome major challenges in the bioprocessing sector, such as design of experiments, process intensification, and high-throughput automation. Timing permitting, the intern will also experience what goes into tech transfer at the early-stage development site. The highly collaborative environment of Sarepta Therapeutics will expose the intern to the nature of the job of multiple teams, departments, and leadership in getting therapeutic molecules from research to the clinic.
Primary Responsibilities Include:
- Assist downstream scientists in the design, preparation, and execution of process development experiments
- Work independently on a research project (selected by the mentor) aimed at optimizing a select unit operation within the downstream process for AAV manufacturing
- Participate in weekly process development meetings
- Refinement of laboratory skills via introduction to new experimental techniques, exposure to current challenges in bioprocess research, and perspectives on the practical aspects of drug development
Desired Education and Skills:
- Undergraduate (junior or senior) or graduate student majoring in a science-oriented field, preferably (but not limited to) chemistry, biochemistry, or bioengineering
- At least one year of laboratory experience (two or more preferred)
Program Timeline:
- This application is for a 10 or 12-week summer internship program that will either start on May 28th or June 10th.
- The program will conclude on August 16th, 2024.
This is a facility-dependent position where in-office presence is required four-five days a week.
#LI-Onsite
This position requires work on site at one of Sarepta's facilities in the United States.
The targeted salary range for this position is $21 - $25 per hour depending upon years of education completed and nature of role.
Candidates must be authorized to work in the U.S.
Sarepta Therapeutics offers a competitive compensation and benefit package.
Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.