Associate Principal Scientist, Haematology Malignancies

We are seeking a highly motivated molecular/cellular biologist, with a track record in basic or applied hematology research to join the Hematology Discovery group as an Associate Principal Scientist. The successful individual will be responsible for identifying and validating new hematological targets, understanding target biology in the setting of progenitor cell populations that includes but is not limited to pre-Malignancy/Multiple Myeloma. These efforts will support the generation of compelling preclinical data packages with an opportunity to participate in a wide range of drug discovery projects and collaborate with scientists across multiple disciplines.
AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. We are more than one of the world's leading pharmaceutical companies.
AstraZeneca has a multifaceted environment that cultivates collaboration and innovation. We attract top minds, and we nurture and build talent.
Within Hematology R&D, we are committed to advancing the science to deliver life-changing medicines to patients most in need. With a combination-focused pipeline that exploits the power of multiple scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy and Epigenetics) to help address unmet clinical needs in a host of hematological cancers, we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of death. This unit has responsibility for the value chain from discovery through to late-stage development, enabling rapid acceleration of promising early-stage assets and life-cycle management programs.
Major Responsibilities-

• Lead efforts to identify and validate hematological targets with a focus on pre malignancy.
• Generation of suitable models including engineered cell lines and PDX ex vivo models
• Design and execution of in vivo/ in vitro studies to support the characterization and development of candidate molecules.
• Genetic manipulation of cells utilizing knockdown or knockout and overexpression of protein for target validation
• Capable of interrogating and hypothesis generation from single cell and other omic data.
• Analyze data and maintain clear experimental records.
• Adept at managing multiple priorities in an efficient and organized manner.
• Using decision making, organizational and communications skills to effectively collaborate with biologist and other scientist from a variety of backgrounds.
• Documentation and presentation of data, findings and experimental conclusions at various meetings including project team and department meetings.

Requirements-

• PHD in biochemistry, cell/molecular biology, genetics, pharmacology, or cancer biology with at least +5 years of experience; industry experience or academic leadership preferred with a commensurate publication record is required.
• Familiarity with multiple assay platforms and technologies including single cell analysis.
• Knowledge and experience with hematological cancers (Multiple Myeloma and NHL).
• Proven track record of success within project teams, including the ability to prioritize, assess, and either continue or adapt projects.
• Excellent oral and written communication skills
• Excellent interpersonal and collaborative skills, and the ability to work independently and effectively in a highly dynamic environment.
• Ability to build and execute a project plan with defined timelines.
• Proven track record of technical proficiency and creativity in experimental design, and independent thinking to achieve short/long-term goals are preferred.

Our Waltham, Massachusetts facility develops life changing small-molecule research in North America, with innovative laboratories at the Gatehouse Park Bio Hub, just west of the city center. Our BioHub facility, is a bold new R&D initiative, which fosters life science discoveries and the exchange of ideas. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. With a shuttle bus to and from Alewife station, the location provides you the ability to work in the heart of one of the world's most vibrant research centers.
Our Waltham site offers a variety of amenities help keep our employees happy and engaged. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams and the greater research community.
As AstraZeneca continues to put patients at the forefront of our mission, we are excited for our move to Kendall Square/Cambridge in 2026. Find out more information here: Kendall Square Press Release
Working at AstraZeneca
Here you'll have the chance to create a substantial difference to patients' lives! With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines - for the world's most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and crafting the patient ecosystem.
Next Steps? Apply now!
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
Date Posted
20-Dec-2023
Closing Date
19-Jan-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.