Address
Form of workAbout Loxo@Lilly:
Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.
The Translational Sciences group is a central node in the Loxo@Lilly drug discovery effort with the mission to inform clinical biomarker strategy, enable clinical decision-making, address regulatory questions, and reverse-translate insights from the clinic to benefit discovery work and next-generation drug development through pre-clinical methods. Focus areas are solidifying the underpinnings for therapeutic mechanisms, understanding indication and patient selection, dose and schedule, differentiation, identifying resistance mechanisms, developing rational combination strategies, and mitigating adverse events.
This is a hands-on position for an experienced lab scientist, who enjoys working at the bench and applying state-of-the-art technology platforms. This scientist must have excellent people and communication skills, and exhibit a positive, "can-do" attitude in a dynamic, fast-paced team focused on rigorous and cutting-edge science to deliver innovative cancer drugs and provide forward-thinking approaches to advance our clinical portfolio.
*Roles and Responsibilities of the Position:
Required Qualifications and Preferred Background:
Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Principal Scientist level could range from between $109,500 to $160,600 and that the base salary for the Scientific Lead could range from between $120,000 to $176,000 and will depend, in part, on the successful candidate's qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel:
The physical demands of this job are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position's work environment is in a lab/bench environment.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.
The Translational Sciences group is a central node in the Loxo@Lilly drug discovery effort with the mission to inform clinical biomarker strategy, enable clinical decision-making, address regulatory questions, and reverse-translate insights from the clinic to benefit discovery work and next-generation drug development through pre-clinical methods. Focus areas are solidifying the underpinnings for therapeutic mechanisms, understanding indication and patient selection, dose and schedule, differentiation, identifying resistance mechanisms, developing rational combination strategies, and mitigating adverse events.
This is a hands-on position for an experienced lab scientist, who enjoys working at the bench and applying state-of-the-art technology platforms. This scientist must have excellent people and communication skills, and exhibit a positive, "can-do" attitude in a dynamic, fast-paced team focused on rigorous and cutting-edge science to deliver innovative cancer drugs and provide forward-thinking approaches to advance our clinical portfolio.
*Roles and Responsibilities of the Position:
- Develop and validate quantitative molecular and mammalian cellular assays to address mechanistic and functional questions in pre-clinical studies.
- Design and execute key experiments to evaluate compound effects, identify combination partners, and investigate drug resistance.
- Translate preclinical findings to biomarkers and combination strategies to advance programs to clinical development.
- Participate in and present in project meetings to ensure assays meet the program needs and results are appropriately interpreted.
- Collaborate with different functional teams throughout the company to guide work toward project goals, communicate ongoing work and progress, and plan forward-thinking strategies.
- Prepare reports for internal and external purposes including regulatory submissions.
- Proactively investigate new or alternative technologies and evaluate service providers to ensure the work is conducted in a scientifically sound, efficient manner.
- Develop and continually advance one's knowledge base on the molecular pathways and the therapeutic area being targeted by our clinical and research programs.
Required Qualifications and Preferred Background:
- Required:
- Ph.D. in Molecular/Cellular Biology or Biochemistry, or related fields with either:
- o 0-5 years of hands-on molecular and cell biology experience in a post-doctoral/research/industry setting
- BS/MS in Molecular/Cellular Biology or Biochemistry with:
- o MS with 6+ years of hands-on molecular and cell biology experience in a biotech/pharma setting or BS with 8+ years of hands-on molecular and cell biology experience in a biotech/pharma setting.
- Experience in developing, running, and troubleshooting molecular and cellular assays; engineering cell models to modulate gene expression and interrogate cellular signal transduction pathways. Experience with primary cell models or co-culture systems is a plus.
- Experience with general molecular biological techniques including vector engineering, cloning and mutagenesis, qRT-PCR, ELISA, MSD and Western Blotting, NGS platforms, FACS, etc.
- Strong background in experimental quantitative analyses, curve-fitting, and statistics (GraphPad Prism).
- Highly organized with excellent documentation and multi-tasking skills.
- Excellent interpersonal skills with the ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.
- Committed to staying current with the latest scientific breakthroughs in the targeted oncology field from target identification through human clinical trials.
- A good and thoughtful listener who values collaboration.
- Enthusiastic, self-motivated, and keen to improve processes and overcome inefficiencies.
- Proficient in Microsoft Office suite and applications.
Ideal candidate will also have/be:
Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Principal Scientist level could range from between $109,500 to $160,600 and that the base salary for the Scientific Lead could range from between $120,000 to $176,000 and will depend, in part, on the successful candidate's qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel:
The physical demands of this job are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position's work environment is in a lab/bench environment.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
