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Form of workScientist, Medicinal Chemistry
Edgewise Therapeutics has an exciting role in a rapidly growing, innovative clinical-stage biopharmaceutical company focused on rare muscle disorders.
About the Position
Edgewise is seeking a synthetic medicinal chemist, eager to contribute to the discovery of novel small-molecule drugs. As a Senior Scientist in Medicinal Chemistry, you will work as part of an interdisciplinary team of scientists to discover novel small molecule therapeutics. You will be responsible for the design and synthesis of novel compounds for ongoing and emerging projects and identification and application of SAR to compound design. You will work in a team-driven environment to achieve optimization of clinical candidates. Responsibilities may also include management of CRO-driven collaborations, work with the CMC team on translation to large scale chemistries of successful candidates, and contribution to patent and publication preparation.
Primary Responsibilities:
Edgewise Therapeutics has an exciting role in a rapidly growing, innovative clinical-stage biopharmaceutical company focused on rare muscle disorders.
About the Position
Edgewise is seeking a synthetic medicinal chemist, eager to contribute to the discovery of novel small-molecule drugs. As a Senior Scientist in Medicinal Chemistry, you will work as part of an interdisciplinary team of scientists to discover novel small molecule therapeutics. You will be responsible for the design and synthesis of novel compounds for ongoing and emerging projects and identification and application of SAR to compound design. You will work in a team-driven environment to achieve optimization of clinical candidates. Responsibilities may also include management of CRO-driven collaborations, work with the CMC team on translation to large scale chemistries of successful candidates, and contribution to patent and publication preparation.
Primary Responsibilities:
- Utilize synthetic organic chemistry to investigate, identify, develop, and optimize methods
- Initiate and execute the design, synthesis, purification and characterization of organic small molecules via multi-step synthesis
- Propose and explore alternative synthetic routes and synthetic strategies, troubleshoot reactions and multistep reaction sequences
- Generation of new scientific synthetic and medicinal chemistry proposals for lead optimization efforts
- Lead the development, execution and/or contribute ideas for novel small molecules based on SAR, X-Ray crystallography and scientific literature
- Oversee and effectively manage CRO chemists
- Interact with vendors to meet program requiements
- Maintain close collaborations and/or manage and mentor fellow chemists and researchers across disciplines in a team environment
- Maintain a command of relevant scientific literature and incorporate into individual project(s) as well as the overall program
- Engage in medicinal chemistry discussions and drive decision-making on compounds
- Prepare and present research results in chemistry and project team meetings and deliver scientific presentations and data to colleagues within and outside the company
- Maintain clear, detailed, and up-to-date records of research using electronic laboratory notebooks
- Manage internal scientific databases
Requirements:
EDUCATION, EXPERIENCE, SKILLS:
EDUCATION, EXPERIENCE, SKILLS:
- Degree in Organic Chemistry with a focus on modern synthetic organic chemistry with typically, 8+ (BS) or 5+(MS) years of experience; Pharmaceutical industry experience desirable
- Understanding of ADME, physicochemical properties, and principles of medicinal chemistry
- Skilled in the art and practice of modern synthetic and mechanistic organic chemistry with demonstrated experience in designing and executing multistep synthesis of complex organic molecules
- Competence with the use of modern spectroscopic methods applied to structure determination including 1H NMR, 13C NMR, IR and mass spectroscopy
- Demonstrate the ability to resolve key scientific hurdles by effectively utilizing available information and technical expertise
- Exceptional communication skills; ability to develop, implement and clearly communicate chemistry strategies and progress to team
- Build strong relationships with peers and cross functionally with partners outside of teams to enable high performance
- Self-motivated with the ability to work independently and effectively in a team-oriented, multidisciplinary environment
- Familiarity with safe and efficient laboratory practices
- General scientific computer and software application proficiency
Salary range: $85,000 – $150,000. Salary will depend on experience level.
