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Who We Are
Cogent Biosciences is a publicly traded biotechnology company developing real solutions to treat genetically driven diseases. With a focus on rational drug discovery and development, we are leveraging validated biology to advance precision therapies designed to address the true underlying drivers of disease and provide real hope for patients. Cogent's lead therapeutic candidate, bezuclastinib (CGT9486), is a precision kinase inhibitor designed to selectively and potently inhibit the KIT D816V mutation. This mutation is responsible for driving a rare and serious condition called Systemic Mastocytosis (SM), which can severely impact many different tissues and organs in the body. We are also studying CGT9486 to treat advanced gastrointestinal stromal tumors (GIST), which have a strong dependence on oncogenic KIT signaling. We are currently enrolling two Phase 2 clinical trials for patients with SM and a global Phase 3 trial for GIST patients.
Our Team
https://cogent.culturehq.com/
The Role
We are looking for a Principal Scientist to join our R&D team out in Boulder, CO. This individual will focus on in-vitro ADME support and will facilitate optimal ADME spending, provide future in-house capabilities, and increase ADME & IVIVC SAR.
Responsibilities
Qualifications
Compensation
Our Locations
Waltham, MA: Our Boston office includes an open office layout that has recently undergone a makeover designed for collaboration and giving our employees the best work place possible. Free access is provided for both on-site parking and gym facilities in the building.
Boulder, CO: We have just moved into our new state-of-the art Research Facility in the fast-growing biopharmaceutical hub in the greater Denver/Boulder corridor. Our CEO is based full-time in this location and we are proud to call this the home of Cogent's discovery research organization.
Our Offer To You
To attract the very best talent, we offer a generous benefits package that includes competitive pay, performance-based bonus, stock options, insurance coverage (health, dental, life, and disability), competitive time-off, a 401(k) plan, and commuter/parking benefits.
We are proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce. We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability, or any other status protected under federal, state, or local law. All employment is decided on the basis of qualifications, merit, and business need.
Covid-19 Vaccination Requirement
In an effort to protect our employees and extended communities from COVID-19, Cogent requires all employees to be fully vaccinated against COVID-19 unless they receive an approved reasonable accommodation for medical or religious reasons.
Who We Are
Cogent Biosciences is a publicly traded biotechnology company developing real solutions to treat genetically driven diseases. With a focus on rational drug discovery and development, we are leveraging validated biology to advance precision therapies designed to address the true underlying drivers of disease and provide real hope for patients. Cogent's lead therapeutic candidate, bezuclastinib (CGT9486), is a precision kinase inhibitor designed to selectively and potently inhibit the KIT D816V mutation. This mutation is responsible for driving a rare and serious condition called Systemic Mastocytosis (SM), which can severely impact many different tissues and organs in the body. We are also studying CGT9486 to treat advanced gastrointestinal stromal tumors (GIST), which have a strong dependence on oncogenic KIT signaling. We are currently enrolling two Phase 2 clinical trials for patients with SM and a global Phase 3 trial for GIST patients.
Our Team
https://cogent.culturehq.com/
The Role
We are looking for a Principal Scientist to join our R&D team out in Boulder, CO. This individual will focus on in-vitro ADME support and will facilitate optimal ADME spending, provide future in-house capabilities, and increase ADME & IVIVC SAR.
Responsibilities
- Manage CROs conducting in-vitro ADME studies.
- Recommend ADME studies to advance NCEs toward PK & IND, as well as for mechanistic information.
- Monitor, revise, and add out-sourced ADME studies to improve data quality, speed, and cost.
- QC in vitro data, protocols, and study reports.
- Collate data regarding SAR trends and IVIVC to present to program teams.
- Contribute to authoring and review of regulatory reports and documents such as INDs.
- Educate others on ADME principles, studies, and interpretation.
- Maintain accurate and timely electronic lab notebook.
- Work effectively both independently & in a team environment.
- Minor in-vitro/in-vivo sample analysis using LC-UV-MS/MS.
- Likely potential for implementation and validation of a small set of mechanistic ADME assays.
Qualifications
- B.S. or higher in Biology, Biochemistry, Chemistry or related field.
- 7+ years of ADME/DMPK experience in biotech/pharma.
- 5+ years of experience using an LC-MS (Sciex preferred)
- Experience with bioanalysis & method development.
- Proven track record de-risking drug-drug interactions (DDIs) and advancing brain penetrant compounds.
- Enzyme kinetics and cell culture background preferred.
- Adept at learning new software and collaborating with Scientific Computing/IT for custom solutions.
- Strong verbal & written communication skills.
- Be able to present in a group setting.
Compensation
- Salary: $120,000 - $180,000
- Target Bonus: 12.5-15%
Exact compensation may vary based on skills, experience, and location.
Our Locations
Waltham, MA: Our Boston office includes an open office layout that has recently undergone a makeover designed for collaboration and giving our employees the best work place possible. Free access is provided for both on-site parking and gym facilities in the building.
Boulder, CO: We have just moved into our new state-of-the art Research Facility in the fast-growing biopharmaceutical hub in the greater Denver/Boulder corridor. Our CEO is based full-time in this location and we are proud to call this the home of Cogent's discovery research organization.
Our Offer To You
To attract the very best talent, we offer a generous benefits package that includes competitive pay, performance-based bonus, stock options, insurance coverage (health, dental, life, and disability), competitive time-off, a 401(k) plan, and commuter/parking benefits.
We are proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce. We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability, or any other status protected under federal, state, or local law. All employment is decided on the basis of qualifications, merit, and business need.
Covid-19 Vaccination Requirement
In an effort to protect our employees and extended communities from COVID-19, Cogent requires all employees to be fully vaccinated against COVID-19 unless they receive an approved reasonable accommodation for medical or religious reasons.
